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|---|---|---|
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| Cat. No. : | HY-B1814 |
| M.Wt: | 173.21 |
| Formula: | C11H11NO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3]. IC50 & Target:IC50: 28 μM (PKM2), 191 μM PKM1, 120 μM (PKL)[2] In Vitro:Vitamin K5 (0-1600 μmoL/L) increases the antibacterial effects of UVA irradiation to Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae[1]. Vitamin K5 (250-1000 μmoL/L) generates superoxide anion radical and hydroxyl radical with a fixed UVA dose of 2.9 J cm-2[1]. Vitamin K5 (0-100 μM; 1 h) dose-dependently inhibits the cellular glucose consumption and lactate production[2]. Vitamin K5 dose-dependently suppresses the proliferation of colon 26 cells[3]. Vitamin K5 induces cell apoptosis and increases activity of caspase-3 in colon 26 cells[3].
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