Sitostanol
CAS No. : 83-45-4
(Synonyms: Stigmastanol; 24α-Ethyl cholestanol)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $850 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-113494 |
| M.Wt: | 416.72 |
| Formula: | C29H52O |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL;Ethanol : 5 mg/mL (ultrasonic) |
Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma[1][2][3][4].
In Vitro:Sitostanol (1.2 μM; 24 h) does not alter mitochondrial respiration in human brown adipocytes or human myotubes, but reduces maximal mitochondrial respiration in human hepatocellular carcinoma HepG2 cells cultured in low-glucose medium[3].
Sitostanol (1.2 μM; 48 h for Treg population) increases the secretion of Th1-type cytokines IFN-γ and IL-2, promotes the number of regulatory T cells (Treg) and IL-10 secretion, reduces the proportion of NK cells, and tends to decrease NKT cell activity in phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from asthma patients[4].
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