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Methylprednisolone


CAS No. : 83-43-2

(Synonyms: U 7532)

83-43-2
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Cat. No. : HY-B0260
M.Wt: 374.47
Formula: C22H30O5
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic)
Introduction of 83-43-2 :

Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3]. IC50 & Target:Glucocorticoid Receptor In Vitro:Methylprednisolone is commonly used for anti-inflammatory purposes. Methylprednisolone can be used in the study of bronchial inflammation or acute bronchitis caused by arthritis and various respiratory diseases[1].
Methylprednisolone can improve neurological recovery in acute spinal cord injury[2].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Based on the blood and multi-tissue concentration-time curves of Methylprednisolone in rats, its tissue distribution was found to be nonlinear, with the highest content in the liver (322.9 ng/ml) and the lowest content in fat (2.74 ng/ml). Due to P-glycoprotein-mediated blood-brain barrier (BBB) efflux transport, Methylprednisolone is poorly distributed in the central nervous system[5].
Methylprednisolone can be used in animal modeling to construct a femoral head necrosis model.
1. Induced osteonecrosis[4]
Background
Methylprednisolone triggers osteoblast death through multiple pathways such as mitochondrial autophagy, ferroptosis and apoptosis, inducing femoral head necrosis.
Specific Modeling Methods
SD Rats • male • 10 weeks old
Administration: 30 mg/kg • im • Injection on the second, third and fourth day
Modeling Indicators
Molecular changes: The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular spacing (Tb.Sp) of the femoral head of rats were significantly reduced.
Phenotypic observation: HE staining evaluation showed an increase in empty pits in rats.
Correlated Product(s) Dexamethasone (HY-14648)
Opposite Product(s) XJB-5-131 (HY-129460)

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