Skatole
CAS No. : 83-34-1
(Synonyms: 3-Methylindole; 3-Methyl-1H-indole)
| Size | Price | Stock |
|---|---|---|
| 5g | $11 | In-stock |
| 10g | $14 | In-stock |
| 25g | $30 | In-stock |
| 100g | $65 | In-stock |
| 500g | $280 | In-stock |
| 1000g | $524 | In-stock |
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| Cat. No. : | HY-W007355 |
| M.Wt: | 131.18 |
| Formula: | C9H9N |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream[1][2].
In Vitro:Skatole (0-1000 μM, 0-72 h) leads to intestinal epithelial cell apoptosis in a time and dose dependent manner[1].
Skatole (1000 μM) activates AhR (48 h) and p38 (30 min) significantly[1].
Skatole (10 μM, 24 h) significantly reverses the suppression of Irisin on Ang II-evoked proliferation, migration, and phenotypic transformation in VSMCs[3].
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