Nafamostat (mesylate)
CAS No. : 82956-11-4
(Synonyms: FUT-175)
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $110 | In-stock |
| 100mg | $158 | In-stock |
| 500mg | $380 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-B0190A |
| M.Wt: | 539.58 |
| Formula: | C21H25N5O8S2 |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall[1][2][3][4].
IC50 & Target:Serine Protease[1][2].
Granzyme[3].
In Vitro:Nafamostat mesylate (10-80 μg/mL, 3-48 h) inhibits NF-κB activity by blocking IκBα phosphorylation in MDAPanc-28 cells[1].
Nafamostat mesylate (80 μg/mL, 24-48 h) induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1) in MDAPanc-28 cells[1].
Nafamostat mesylate (0.1-10 μM, 24 h) has suppressive effect on invasiveness in Panc-1 cells[2].
In Vivo:Nafamostat mesylate (10 mg/kg, Intraperitoneal injection, once a day for 18 days) exhibits favourable antiviral effects against Zika virus (ZIKV) infection in A129 mice[3].
Nafamostat mesylate (0.5-2.0 mg/mL (dissolved in saline), Intraperitoneal injection, once a day for 7 consecutive days) has inhibitory effect on neointimal formation after balloon injury of the rat carotid wall[4].
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