Asp-AMS
CAS No. : 828288-98-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $700 | In-stock |
| 25mg | $1400 | In-stock |
| 50mg | $2200 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-112860 |
| M.Wt: | 461.41 |
| Formula: | C14H19N7O9S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme. IC50 & Target:Aspartyl-tRNA synthetase, Mitochondrial enzyme [1]. In Vitro: Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].
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