Valategrast (hydrochloride)


CAS No. : 828271-96-1

(Synonyms: R-411)

828271-96-1
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Cat. No. : HY-14189
M.Wt: 641.41
Formula: C30H33Cl4N3O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 828271-96-1 :

Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. IC50 & Target: Integrin α4β1; Integrin α4β7[2] In Vitro: Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].

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