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|---|---|---|
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| Cat. No. : | HY-14189 |
| M.Wt: | 641.41 |
| Formula: | C30H33Cl4N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. IC50 & Target: Integrin α4β1; Integrin α4β7[2] In Vitro: Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].
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