GW-870086
CAS No. : 827319-43-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $58 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $174 | In-stock |
| 50mg | $265 | In-stock |
| 100mg | $395 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103662 |
| M.Wt: | 559.64 |
| Formula: | C31H39F2NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB. IC50 & Target: pIC50: 10.1 (glucocorticoid receptor, A549 NF-κB cells)[1] In Vitro: GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2)[1]. GW-870086 (GW870086X; 10-100 nM) significantly increases fibronectin secretion. However, GW-870086 has no effect on MMP2 secretion, and does not increase cellular myocilin[2].
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