U-99194
CAS No. : 82668-33-5
(Synonyms: U-99194A (free base); PNU-99194A; JPC-211)
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| Cat. No. : | HY-12701 |
| M.Wt: | 277.40 |
| Formula: | C17H27NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].
In Vitro:U-99194 (1 μM, 15 min) prevents the cocaine-induced inhibition of monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
U-99194 (1 μM) blocks the inhibitory effect of PD 128907 ( HY-100539) on the amplitude of monosynaptic IPSCs evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
In Vivo:U-99194 (30 mg/kg, i.p., once) significantly suppresses Nicotine (HY-127019)-induced tremor in mice[1].
U-99194 (30 μg/site, intracerebellar microinjection, once) markedly inhibits Nicotine-induced tremor in rats[1].
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