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ML335


CAS No. : 825658-06-8

825658-06-8
Price and Availability of CAS No. : 825658-06-8
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Cat. No. : HY-104005
M.Wt: 373.25
Formula: C15H14Cl2N2O3S
Purity: >98 %
Solubility: DMSO : 155 mg/mL (ultrasonic;warming)
Introduction of 825658-06-8 :

ML335 is a selective activator of both TREK-1 and TREK-2. IC50 & Target: TREK-1, TREK-2 In Vitro: Xenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K2P2.1 and K2P10.1 but not K2P4.1 (14.3±2.7 μM, K2P2.1-ML335; 13.7±7.0 μM, K2P2.1-ML402; 5.2±0.5 μM, K2P10.1-ML335; and 5.9±1.6 μM, K2P10.1-ML402). Swapping the Lys271 equivalent between K2P2.1 and K2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8 μM and 5.9±1.6 μM for ML335 and ML402, respectively (n≥3))[1].

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