Pseudolaric Acid B

Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2^{[1][2][3][4][5]}. In Vitro:Pseudolaric Acid B (4 μM; 36 h to 3 days) activates autophagy in MCF‑7 human breast cancer cells to prevent cell death^[1].
Pseudolaric Acid B (4 μM; 0-36 h) inhibits the secretion of hepatitis B virus (HBV) by inducing apoptosis and cell cycle arrest^[2].
Pseudolaric Acid B (0.313-10 μM; 6-72 h) inhibits the proliferation, migration and tube formation of HUVEC, and reduces the secretion of VEGF by tumor cells, which is related to proteasoma-mediated HIF-1α protein degradation^[3]. In Vivo:Pseudolaric Acid B (Oral gavage; 10-20 mg/kg; 3 days) has anti-fertility ability in rats, which may be related to the maternal vascular system^[4].