FEN1-IN-1
CAS No. : 824983-91-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $28 | In-stock |
| 5mg | $60 | In-stock |
| 10mg | $90 | In-stock |
| 50mg | $190 | In-stock |
| 100mg | $290 | In-stock |
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| Cat. No. : | HY-123834 |
| M.Wt: | 332.33 |
| Formula: | C15H12N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1].
IC50 & Target:FEN1[1]
In Vitro:FEN1-IN-1 (0-30 μM, 3 days) inhibits 212 cell-lines growth with a mean GI 50 of 15.5 μM[1].
FEN1-IN-1 (0.2-20 μM, 24 h) induces Hela cells disrupted for MRE11A more sensitive and decreasea the survival of the MRE11A deficient cell-lines due to cytotoxicity[1].
FEN1-IN-1 (0-10 μM, 24 h) inhibits both FEN1 and EXO1 function and induces a DNA damage response to activate the signalling pathways in SW620 and HCT-116 cells[1].
FEN1-IN-1 (10 μM, 24 h) leads to replication fork instabilities that, if left unrepaired, can lead to cell death[1].
Tissue-specific sensitivity to FEN1-IN-1 (GI50: μM)[1]
| FEN1-IN-1 | Bladder | Breast | Colorectal | Gastric | Liver | Lung | Pancreatic | Prostate | Gynae | Head & Neck |
| Cell-lines screened | 19 | 22 | 21 | 25 | 21 | 37- | 24 | 7 | 21 | 15 |