CHAPSO
CAS No. : 82473-24-3
(Synonyms: 3-[3-(Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate)
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| 25g | $381 | In-stock |
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| Cat. No. : | HY-W040201 |
| M.Wt: | 630.88 |
| Formula: | C32H58N2O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CHAPSO is a bile derivative. CHAPSO reduces protein adsorption, improves the cryo-EM imaging quality. CHAPSO can be used as a detergent, or as the membrane protein solubilization and reconstruction reagent in membrane protein structural studies[1][2][3].
In Vitro:CHAPSO prevents bacterial transcription complexes from adsorbing on the air/water interface during cryo-EM grid preparation, thereby avoiding the generation of orientation bias. CHAPSO can be used for Cryo-EM sample preparation and Cryo-EM tomography[2].
CHAPSO forms a monolayer covering the air/water interface at the critical micelle concentration (CMC), changing the surface properties of the interface and preventing particle adsorption[2].
CHAPSO dissolves liposomes and membrane proteins, releasing them from lipid bilayer structures[3].
CHAPSO can be used to prepare phospholipid bilayers with specific orientations for nuclear magnetic resonance experiments[3].
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