(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane

(+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane ((S,S)-Ph-BPE) is a chiral bisphosphine ligand and catalyst. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane acts as a chiral ligand in rhodium-catalyzed reductive hydroformylation of alkenyl boronic esters, enabling enantiodivergent synthesis of chiral γ-boryl alcohols. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms chiral nickel-phosphine complexes to mediate asymmetric hydrogenation of aliphatic γ- and δ-keto acids; protons promote substrate C₌O bond activation and stereoselectivity control via hydrogen bonding. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms a monodentate nickel complex, which serves as the active species for asymmetric hydrogenation of aliphatic keto acids^[1][2]. In Vitro:(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane ((S,S)-Ph-BPE) acts as a chiral ligand in Rh-catalyzed reductive hydroformylation of aryl-substituted alkene 1,2-diboronic esters, enabling formation of chiral 1,3-diols^[1].
(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane induces enantiodivergence in Rh-catalyzed reductive hydroformylation of alkene 1,2-diboronic esters and α-substituted alkenyl boronic esters via energy differences in the enantio-determining olefin insertion transition states, producing chiral products with opposite configurations^[1].
(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane (0.0133-1 mol%; 12-24 h) forms a highly active homogeneous chiral nickel-phosphine complex that catalyzes the asymmetric hydrogenation of aliphatic γ- and δ-ketoacids, including biomass-derived levulinic acid, to produce chiral lactones with up to 98% yield, 99% ee, and a maximum substrate-to-catalyst ratio of 7500^[2].