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2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside


CAS No. : 82373-94-2

(Synonyms: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside)

82373-94-2
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Cat. No. : HY-N0652
M.Wt: 406.39
Formula: C20H22O9
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 10 mg/mL (ultrasonic)
Introduction of 82373-94-2 :

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions[1][2]. In Vitro:2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) inhibits LPS-induced expression of pro-inflammatory cytokine (IL-6 and TNF-α) in RAW264.7 cells[3].
2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) inhibits the expression of NO and mRNA levels of proinflammatory cytokine (IL-1β, IL-6, TNF-α and COX-2. ) in RAW264.7 cells[3].
2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) suppresses NF-κB signaling pathway and ERK2 activation in LPS-induced RAW264.7 cells[3].
In Vivo:2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (30-60 mg/kg, i.p., daily, 7 days) can be used to cope with depressive-like symptoms in male ICR mice by inhibition of neuroinflammation and oxido-nitrosative stress[2].

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