Atomoxetine (hydrochloride)


CAS No. : 82248-59-7

(Synonyms: Tomoxetine (hydrochloride); (R)-Tomoxetine (hydrochloride); LY 139603)

82248-59-7
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Cat. No. : HY-17385
M.Wt: 291.82
Formula: C17H22ClNO
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL;H2O : 50 mg/mL (ultrasonic)
Introduction of 82248-59-7 :

Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. In Vitro:Atomoxetine (Tomoxetine) (1-100 µM; 0.5-20 seconds; tsA201 cells) hydrochloride interacts with the human heart muscle sodium channel (hNav1.5) in a state and dose-dependent manner[2]. In Vivo:Atomoxetine (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) hydrochlorideincreases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1].
Atomoxetine (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) hydrochloride can improve behaviors associated with ADHD in rats[3].

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