Epalrestat
CAS No. : 82159-09-9
(Synonyms: ONO2235)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 50mg | $110 | In-stock |
| 100mg | $176 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-66009 |
| M.Wt: | 319.40 |
| Formula: | C15H13NO3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy[1][2][3].
In Vitro:Epalrestat (100 and 200 µM, 24 h) inhibits cell viability and induces cell apoptosis in rat Schwann cells (SCs)[5].
Epalrestat (10 and 50 µM, 24 h) increases intracellular glutathione levels in rat SCs by up-regulating γ-GCS via Nrf2 activation[5].
Epalrestat (50 µM, 16 h) protects SCs from oxidative stress[5].
In Vivo:Epalrestat (0.08% (w/w) in regular chow, 8 weeks) shows nephritic protective effect in diabetic nephropathy in db/db mice[4].
Epalrestat (100 mg/kg, i.g., daily for 6 weeks) protects rats from diabetic peripheral nerve injury in diabetic peripheral neuropathy (DPN) model induced by Streptozotocin (HY-13753)[6].
Epalrestat (50 mg/kg, oral gavage, twice a day) reduces cerebral ischemia-induced infarct volume and BBB permeability in mice[7].
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