Tiprelestat
CAS No. : 820211-82-3
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| Cat. No. : | HY-106216 |
| M.Wt: | 5999.09 |
| Formula: | C254H416N72O75S10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1].
In Vitro: Tiprelestat (4 and 8 μM) inhibits P. aeruginosa-secreted peptidase[3].
Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells[4].
Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells[4].
In Vivo: Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O2 mice[2].
Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice[5].
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