KW-2478 (hydrochloride)
CAS No. : 819812-18-5
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| Cat. No. : | HY-13468A |
| M.Wt: | 611.12 |
| Formula: | C30H43ClN2O9 |
| Purity: | >98 % |
| Solubility: |
KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer[1][2].
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