NTU281
CAS No. : 815619-12-6
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| Cat. No. : | HY-100446 |
| M.Wt: | 487.59 |
| Formula: | C25H31N2O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes[1][2]. In Vivo: NTU281 (2.5 μl/h of 50 mM; cannulate to deliver into kidneys) reduces glomerular collagen I overexpression as well as the increases in glomerular Hic-5 and α-SMA expression; also decreases serum creatinine, albuminuria, glomerulosclerosis and tubulointerstitial scarring in diabetic rats[1][2].
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