Nafamostat
CAS No. : 81525-10-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | Get quote |
| 10mg | $304 | Get quote |
| 25mg | $495 | Get quote |
| 50mg | $690 | Get quote |
| 100mg | $950 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-B0190 |
| M.Wt: | 347.37 |
| Formula: | C19H17N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nafamostat, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall[1][2][3][4].
In Vitro:Nafamostat (10-80 μg/mL, 3-48 h) inhibits NF-κB activity by blocking IκBα phosphorylation in MDAPanc-28 cells[1].
Nafamostat (80 μg/mL, 24-48 h) induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1) in MDAPanc-28 cells[1].
Nafamostat (0.1-10 μM, 24 h) has suppressive effect on invasiveness in Panc-1 cells[2].
In Vivo:Nafamostat (10 mg/kg, Intraperitoneal injection, once a day for 18 days) exhibits favourable antiviral effects against Zika virus (ZIKV) infection in A129 mice[3].
Nafamostat (0.5-2.0 mg/mL (dissolved in saline), Intraperitoneal injection, once a day for 7 consecutive days) has inhibitory effect on neointimal formation after balloon injury of the rat carotid wall[4].
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