Nipradolol
CAS No. : 81486-22-8
(Synonyms: KT 210; K 351; Hypadil)
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| Cat. No. : | HY-106523 |
| M.Wt: | 326.34 |
| Formula: | C15H22N2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery[1][2].
In Vitro:Nipradolol (1 μM; 10 min) inhibits K-induced contraction in dog muscles with an ID50 value of 0.8 μM[1].
Nipradolol (1 μM; 10 min) reduces the resting tone and to suppress the NA-induced contraction in proximal region[1].
In Vivo:Nipradolol (0.125%, 0.25%, 0.5%; I.V.; single dose) inhibits the increase in IOP in a concentration-dependent manner on rabbits’ eyes[2].
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