Lactic acid (calcium)

Lactic acid (DL-Lactic acid) calcium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid calcium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid calcium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity^[1][2]. Lactic acid calcium also has antimicrobial activity, which can be used as a food preservative^[3]. In Vitro:Lactic acid (20 mM; 24, 48 h) calcium results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation^[1].
Lactic acid (20 mM; 24 h) calcium shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1^[1].
In Vivo:Lactic acid (1.6 g/kg; pH 7.4; subcutaneous; daily from Day 8 to 30 days) calcium shows CD8+ T cell-dependent tumor growth inhibition in MC38 colon cancer model^[2].
Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.