EMD 495235
CAS No. : 811811-33-3
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| Cat. No. : | HY-10777 |
| M.Wt: | 451.92 |
| Formula: | C20H22ClN3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities[1].
IC50 & Target:IC50: 5.5 nM (factor Xa)[1].
Ki: 6.8 nM (human factor Xa)[1].
In Vivo:EMD 495235 is characterized by rapid absorption from the gastrointestinal tract, plasma elimination half-lives of 0.57-2.3 h, a clearance between 0.25 and 1.3L/h/kg and absolute bioavailability of 60-80% in Wistar rats, Beagle dogs and Cynomolgus monkeys[1].
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