Cilastatin (sodium)
CAS No. : 81129-83-1
(Synonyms: MK0791 (sodium))
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $108 | In-stock |
| 100mg | $168 | In-stock |
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| Cat. No. : | HY-A0166A |
| M.Wt: | 380.43 |
| Formula: | C16H25N2NaO5S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3]. IC50 & Target:IC50: 0.1 μM (Renal dehydropeptidase I); 178 μM (Bacterial metallob-lactamase enzyme CphA)[1] In Vitro:Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin[2]. In Vivo:In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus, E. coli, and P. aeruginosa infection[3].
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