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Warfarin


CAS No. : 81-81-2

(Synonyms: WARF-42; Athrombine-K)

81-81-2
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Cat. No. : HY-B0687
M.Wt: 308.33
Formula: C19H16O4
Purity: >98 %
Solubility: H2O : 0.1 mg/mL (ultrasonic);DMSO : ≥ 50 mg/mL
Introduction of 81-81-2 :

Warfarin (WARF-42; Athrombine-K) is a potent anticoagulant agent and a vitamin K1 recycling antagonist to deplete active vitamin K1. Warfarin decreases blood coagulation and prevents blood clot formation by inhibiting vitamin K epoxide reductase. Warfarin can be taken orally[1][2]. IC50 & Target:IC50: vitamin K1 recycling[1] In Vivo:Zymosan A can be used in animal modeling to establish a mouse peritonitis model.
Zymosan A (25.0 mg/kg; IP at 12 and 2 h before IR) mitigates IR-induced intestinal injury in mice[1].

Induction of arterial calcification[3]

Background
Warfarin promotes vascular calcification by affecting the synthesis of vitamin K-dependent proteins.
Specific Mmodeling Methods
Rats: 7-week-old • male Sprague-Dawley rats Dosage: 3 mg/g food • oral • for two weeks
Note
(1) Two weeks after Warfarin administration, EPA was administered to test the prevention of arterial calcification[3].
Modeling Indicators
Tissue changes: Intraarterial calcification, elastic fiber disorder and rupture, and macrophage infiltration were found in the abdominal aorta and common iliac arteries[3].
Molecular changes: Total cholesterol and triglyceride levels increased, OPN and ALP expressions decreased, and MCP-1 and MMP-9 expressions increased[3].
Correlated Product(s): /
Opposite Product(s): Eicosapentaenoic Acid (HY-B0660)

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