1,8-Dihydroxy-4,5-dinitroanthraquinone
CAS No. : 81-55-0
(Synonyms: ARDP0006; DHDNE)
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| Cat. No. : | HY-121138 |
| M.Wt: | 330.21 |
| Formula: | C14H6N2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C) |
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].
In Vitro:1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells[1].
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells[1].
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