Cholic acid
CAS No. : 81-25-4
| Size | Price | Stock |
|---|---|---|
| 5g | $23 | In-stock |
| 25g | $34 | In-stock |
| 100g | $112 | In-stock |
| 500g | $233 | In-stock |
| 1000g | $465 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-N0324 |
| M.Wt: | 408.57 |
| Formula: | C24H40O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : < 0.1 mg/mL;0.1 M NaOH : 33.33 mg/mL (ultrasonic;adjust pH to 9 with NaOH) |
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active[1][2]. In Vitro: Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. In Vivo: Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2].
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