D-Panthenol

D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration. In Vitro: D-panthenol exhibits neuroprotective activity against tBHP (0-100 μM) and FESO₄ (0.5 mM) induced oxidation in mitochondria through inhibiting lipid peroxidation, thereby improves mitochondrial metabolism, reverses redox potential of the glutathione system and decreases the level of S-glutathionylated proteins^[4]. In Vivo: D-panthenol (200 mg/kg, i.p. for 7 days) enhances tolerance of kidney tissues against oxidative damage through limited lipid peroxidation and SOD activity in Rhabdomyolysis-Induced AKI in Wistar mice^[2].
D-panthenol (200 mg/kg, i.p. for 7 days) exhibits nephroprotective effect through inhibiting inflammatory processes with decreased MPO activity and leukocyte infiltration in Rhabdomyolysis-Induced AKI in Wistar mice ^[2].
D-panthenol (4 mg as a spray, twice a day for 14 days) promotes wound healing through retaining the environment moisture, promoting tissue repair and regeneration in streptozotocin-induced diabetes mellitus C57BL/6 mice and db/db mice^[3].