Roxadustat
CAS No. : 808118-40-3
(Synonyms: FG-4592)
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $85 | In-stock |
| 50mg | $108 | In-stock |
| 100mg | $144 | In-stock |
| 200mg | $228 | In-stock |
| 500mg | $348 | In-stock |
| 1g | $540 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-13426 |
| M.Wt: | 352.34 |
| Formula: | C19H16N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Roxadustat is an orally active hypoxia-inducible factor prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].
IC50 & Target:Hypoxia-inducible factor prolyl-hydroxylase[1]
In Vitro:Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells[2].
Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells[2].
In Vivo:Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury[2].
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