Docebenone
CAS No. : 80809-81-0
(Synonyms: AA 861)
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $640 | In-stock |
| 25mg | $1200 | In-stock |
| 50mg | $1750 | In-stock |
| 100mg | $2450 | In-stock |
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| Cat. No. : | HY-12886 |
| M.Wt: | 326.43 |
| Formula: | C21H26O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. IC50 & Target: 5-LO[1]. In Vitro: Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production[1]. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently[2]. In Vivo: Docebenone might protect experimental acute necrotizing pancreatitis in rats[3]. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M[4].
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