Sancycline
CAS No. : 808-26-4
(Synonyms: Bonomycin; 6-Demethyl-6-deoxytetracycline)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $260 | In-stock |
| 100mg | $390 | In-stock |
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| Cat. No. : | HY-17466 |
| M.Wt: | 414.41 |
| Formula: | C21H22N2O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
In Vitro:Sancycline (400 μM, 24 h) decreases 2 chloroethyl ethyl sulfide (CEES) and nitrogen mustard (NM) induced corneal injuries and inhibits Matrix metalloproteinase (MMP)-9 expression to some degree in the basement membrane zone (BMZ) increased by NM[2].
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