SKF-82958
CAS No. : 80751-65-1
(Synonyms: (±)-SKF-82958; Chloro-APB)
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| Cat. No. : | HY-10435 |
| M.Wt: | 329.82 |
| Formula: | C19H20ClNO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1].
In Vivo: SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].
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