Semax
CAS No. : 80714-61-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $430 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-P1146 |
| M.Wt: | 813.92 |
| Formula: | C37H51N9O10S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].
In Vitro:Semax (25-100 μM, 48 h) can reduce the levels of Aβ oligomers[1].
Semax (100 nM) can increase the survival rate of cholinergic neurons in the basal forebrain and stimulate the activity of choline acetyltransferase in cultured basal forebrain tissue ex vivo[2].
Semax (10 μM, 0-4 h) can increase the levels of BDNF and NGF in glial cells derived from the basal forebrain of newborn rats[3].
In Vivo:Semax (100 μg/kg; intraperitoneal injection; single dose) has an ameliorating effect in a rat model of focal cerebral ischemia[4].
Semax (0.15 mg/kg; intraperitoneal injection; single dose) can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice[5].
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