Edatrexate


CAS No. : 80576-83-6

(Synonyms: CGP 30694)

80576-83-6
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Cat. No. : HY-13617
M.Wt: 467.48
Formula: C22H25N7O5
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 80576-83-6 :

Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck[1][2]. In Vivo:Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX[1].

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