Balsalazide
CAS No. : 80573-04-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $195 | In-stock |
| 100mg | $290 | In-stock |
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| Cat. No. : | HY-B0667 |
| M.Wt: | 357.32 |
| Formula: | C17H15N3O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);1M NaOH : 50 mg/mL (ultrasonic;adjust pH to 12 with NaOH) |
Balsalazide is a prodrug of amino salicylic acid that releases mesalamine (HY-15027) in the colon, offering various anti-inflammatory effects in areas of colitis, and it also exerts related anticancer effects by regulating the IL-6/STAT3 pathway[1][2][3]. In Vivo:At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
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