PHTPP
CAS No. : 805239-56-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $96 | In-stock |
| 25mg | $192 | In-stock |
| 50mg | $307 | In-stock |
| 100mg | $491 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103456 |
| M.Wt: | 423.31 |
| Formula: | C20H11F6N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 15.38 mg/mL (ultrasonic) |
PHTPP is a selective estrogen receptor β (ERβ) antagonist with 36-fold selectivity over ERα[1]. IC50 & Target: ERβ[1] In Vitro: PHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP[1]. PHTPP (10-6 M) inhibits E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10-6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression[2].
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