Dynorphin A
CAS No. : 80448-90-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $77 | In-stock |
| 5mg | $297 | In-stock |
| 10mg | $407 | In-stock |
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| Cat. No. : | HY-P1333 |
| M.Wt: | 2147.48 |
| Formula: | C99H155N31O23 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease[1][2].
In Vitro: Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death[3].
dynorphin A (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons[4].
dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe[5].
In Vivo: Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats[5].
Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain[6].
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