Gynostemma Extract
CAS No. : 80321-63-7
(Synonyms: Ginsenoside C-Mx1; Gypenoside IX)
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $306 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $960 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-N0167 |
| M.Wt: | 917.13 |
| Formula: | C47H80O17 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation[1][2].
In Vitro:Gynostemma Extract (3.125-50 μM; 24 h) shows no cytotoxicity on C6 cells[2].
Gynostemma Extract (3.125-50 μM; 2 h) dose-dependently reduces NO production in C6 cells stimulated by LPS and TNF-α, with an IC50 of around 25 μM [2].
In Vivo:Gynostemma Extract (30 mg/kg; i.p.) reduces the production of TNF-α, IL-6, and iNOS at protein levels, alleviates astrogliosis, and impedes the elevation of GFAP in brain cortex of LPS-induced C57BL/6 mice[2].
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