Metoprolol (fumarate)


CAS No. : 80274-67-5

(Synonyms: CGP 2175C; Lopressor OROS)

80274-67-5
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Cat. No. : HY-17503C
M.Wt: 650.80
Formula: C34H54N2O10
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 80274-67-5 :

Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3]. In Vitro: Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently[3]. In Vivo: Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE?/? Mice[1].
Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis[2].
Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats[4].

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