Prostaglandin E3
CAS No. : 802-31-3
| Size | Price | Stock |
|---|---|---|
| 1.43 mM * 200 μL in Methyl acetate | $650 | Get quote |
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| Cat. No. : | HY-113481 |
| M.Wt: | 350.45 |
| Formula: | C20H30O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity[1].
In Vitro:Prostaglandin E3 (1-10000 nM) suppresses M1 and induces M2a marker expression in polarized macrophages[1].
In Vivo:Prostaglandin E3 (1 µmol/L; i.p.) modulates macrophage polarization towards an anti-inflammatory function in LPS (HY-D1056) (5 mg/kg)-induces acute inflammation model[1].
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization[1].
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