Mancozeb
CAS No. : 8018-01-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $25 | In-stock |
| 500mg | $50 | In-stock |
| 1g | $90 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B0854 |
| M.Wt: | 661.36 |
| Formula: | C8H12Mn2N4S8Zn2 2- |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C);DMSO : 1 mg/mL (ultrasonic) |
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4].
In Vitro:Mancozeb (0.1-500 ppm; 24-48 h) is highly toxic to HepG2 cells, and can affect cell metabolism and induce cell damage[2].
In Vivo:Mancozeb (0-300 mg/kg; Take orally; At 30 days) causes liver injury in mice by activating Keap1/Nrf2 signaling pathway, but was alleviated by Glycyrrhiza polysaccharides[3].
Mancozeb (100 mg/kg; Gavage; 30 days) can cause ovarian injury and apoptosis in mice[4].
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