Homatropine (methylbromide)
CAS No. : 80-49-9
(Synonyms: Homatropine methobromide)
| Size | Price | Stock |
|---|---|---|
| 50mg | $60 | In-stock |
| 100mg | $72 | In-stock |
| 200mg | $120 | In-stock |
| 500mg | $180 | In-stock |
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| Cat. No. : | HY-B1388 |
| M.Wt: | 370.28 |
| Formula: | C17H24BrNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL;H2O : ≥ 100 mg/mL |
Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. IC50 & Target:IC50: WKY-E (162.5 nM), SHR-E (170.4 nM) In Vitro:Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. In Vivo:Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.
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