Hexaconazole
CAS No. : 79983-71-4
(Synonyms: (-)-Hexaconazol)
| Size | Price | Stock |
|---|---|---|
| 50mg | $30 | In-stock |
| 100mg | $45 | In-stock |
| 500mg | $65 | In-stock |
| 1g | $80 | In-stock |
| 5g | $155 | In-stock |
| 10g | $195 | In-stock |
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| Cat. No. : | HY-A0278 |
| M.Wt: | 314.21 |
| Formula: | C14H17Cl2N3O |
| Purity: | >98 % |
| Solubility: | H2O : 0.67 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
Hexaconazole is a demethylation enzyme inhibitor and a synthetic fungicide that targets many fungi, especially ascomycetes and basidiomycetes, and it can enhance the activity of SOD and peroxidase. Hexaconazole causes endocrine disorders in zebrafish larvae[1][2][3][4].
In Vitro:Hexaconazole has a sensitivity range of 0.06-4.33 μg/mL against Fusarium graminearum, with an average EC50 of 0.78 μg/mL[1].
Hexaconazole-resistant strains of Fusarium graminearum show reduced mycelial growth and pathogenicity, which affects asexual reproduction[1].
Hexaconazole (0.6 μg/mL, 18 h) downregulates the expression of the FgCYP51 gene in sensitive strains of Fusarium graminearum[1].
Hexaconazole prevents the demethylation of lanosterol catalyzed by cytochrome P450 (CYP51), thereby blocking the biosynthesis of ergosterol, leading to damage to the cell membrane[1].
In Vivo:Hexaconazole (0.625-2.5 mg/mL, exposure, 120 h) alters thyroid hormone levels and HPT axis gene transcription in zebrafish larvae[2].
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