Idazoxan (hydrochloride)


CAS No. : 79944-56-2

(Synonyms: RX 781094 (hydrochloride))

79944-56-2
Price and Availability of CAS No. : 79944-56-2
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5mg $55 In-stock
10mg $88 In-stock
25mg $165 In-stock
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Cat. No. : HY-14561A
M.Wt: 240.69
Formula: C11H13ClN2O2
Purity: >98 %
Solubility: H2O : 100 mg/mL (ultrasonic);DMSO : 125 mg/mL (ultrasonic)
Introduction of 79944-56-2 :

Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. IC50 & Target: α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2] In Vivo: Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

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