Sofiniclin
CAS No. : 799279-80-4
(Synonyms: ABT 894)
| Size | Price | Stock |
|---|---|---|
| 1mg | $330 | In-stock |
| 5mg | $680 | In-stock |
| 10mg | $1090 | In-stock |
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| Cat. No. : | HY-14824 |
| M.Wt: | 244.13 |
| Formula: | C10H11Cl2N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 35.71 mg/mL (ultrasonic;warming;heat to 60°C) |
Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR), is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD)[1][2]. In Vitro: Sofiniclin is more potent than ABT-089 at both receptor subtypes, with Ki values of 1.9 nM for 125I-α-conotoxinMII binding and of 1.3 nM for 125I-epibatidine binding[1]. In Vivo: Sofiniclin (0.001 to 0.10 mg/kg, p.o.) produces significant reductions in LIDs compared to vehicle monkey[1]. Sofiniclin (0.1 mg/kg) does not decrease LIDs in monkeys with severe nigrostriatal damage[2].
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