Forsythiaside A

Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D^[1][2][3][4]. In Vitro:Forsythiaside A 在 30 μM 时抑制 COX-2，抑制率为 72%^[2]。
Forsythiaside A (80 μM；30 分钟) 通过降低 Aβ_25-35（5 μM；2 小时）处理的器官型海马 ampal 切片中的 MAGL 表达来增加内源 2-AG 的含量^[2]。
Forsythiaside A (80 μM；30 分钟) 以 CB1R 依赖性方式预防 Aβ_25-35 诱导的神经炎症^[2]。
Forsythiaside A (2.5-10 μg/mL；12 h) 抑制肺上皮细胞Nrf2信号通路^[3]。
In Vivo:Forsythiaside A (15-60 mg/kg; single dose; oral) improves OVA-induced asthma models in mice, dose-dependently activates Nrf2/HO-1 signaling, and attenuates OVA-induced lung histopathology^[3].