Castanospermine
CAS No. : 79831-76-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $88 | In-stock |
| 50mg | $106 | In-stock |
| 100mg | $132 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N2022 |
| M.Wt: | 189.21 |
| Formula: | C8H15NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Castanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection[1][2][3][4].
In Vitro:Castanospermine (0.01-1000 μM, 48 h) inhibits the production of DEN infectious virus in a dose-dependent manner and slows the electrophoretic mobility of DEN prM (a glycosylated structural protein) in BGK-21 cells[1].
In Vivo:Castanospermine (10, 50, 250 mg/kg, i.p., a single dose for 10 consecutive days) can improve the survival rate of mice infected with DEN-2 virus[1].
Castanospermine (10-500 mg/kg, intraperitoneal injection) can improve the symptoms of acute pancreatic injury in rats[2].
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