β-Secretase Inhibitor IV
CAS No. : 797035-11-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $770 | In-stock |
| 10mg | $1230 | In-stock |
| 25mg | $2460 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-10133 |
| M.Wt: | 578.72 |
| Formula: | C31H38N4O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. IC50 & Target: IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1] In Vitro: In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1].
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