Linifanib (GMP)
CAS No. : 796967-16-3
(Synonyms: ABT-869 (GMP); AL-39324 (GMP))
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| Cat. No. : | HY-50751G |
| M.Wt: | 375.40 |
| Formula: | C21H18FN5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells[1].
IC50 & Target:IC50: 4 nM (KDR), 4 nM (FLT1), 66 nM (PDGFRβ), 3 nM (CSF-1R), 4 nM (FLT3), 14 nM (Kit)[1]
In Vitro:Linifanib (GMP) (1 μM) induces generation of hCiPS cells from human embryonic fibroblasts (HEFs)[1].
Linifanib (GMP) (1 μM) induces generation of hCiPS cells from hADSCs or hASFs[1].
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